Hypothyroid Cause #4 of 6
Why do people still feel bad when taking thyroid medications? Because there is another reason other than your thyroid hormone quantities! Join Dr. Shook to learn more…
Why do people still feel bad when taking thyroid medications? Because there is another reason other than your thyroid hormone quantities! Join Dr. Shook to learn more…
We understand that thyroid problems are complicated and that is why Dr. Shook has created several resources so that you can be your own advocate and take your health back!
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You may want to begin with Dr. Shook’s lab guide, “9 Tests Required to Understand Your Thyroid,” and take a look at a a few of the resources below:
1) HAIR LOSS "How Can I Prevent Hair Loss With Hashimoto's?"
https://hashimotosdoctor.com/free-guide-plus-hostin g-feeqht…
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More...
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You can read the transcript of this video below: 6 Patterns of Hypothyroidism, #4 of 6 The Over Conversion Pattern
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| Hey guys, Dr. Shook here. Hope you're doing well today. Today what |
| Today we're going to talk about thyroid over conversion, so converting, if you've seen any of the previous videos that I've done on its patterns you know that one of the previous patterns that I discussed was thyroid hormone under-conversion. That's where the T4 did not convert well into T3 so you have low T3 due to under-conversion. Today we're talking about over-conversion and low TBG or thyroid-binding globulins. The thyroid binding globulins are these blue little things here we're going to talk about in a minute that |
| Let's go ahead and get started. Let's talk about how it works again briefly and then we'll talk about how this particular pattern is breaking down. Some of the labs that you'll see and then some of the potential causes which are behind it. How does it work? Remember the brain, a central structure in the brain called the hypothalamus makes thyroid releasing hormone. Thyroid releasing hormone stimulates the pituitary gland which is a brain-based structure. The pituitary gland secretes thyroid stimulating hormone or TSH, and the thyroid stimulating hormone drives the thyroid function. It drives the thyroid metabolism. TSH stimulates the thyroid to produce T4 and T3 as your primary thyroid hormones. T4 is ninety-three percent of the hormone produced, T3 is seven percent. Remember T4 is primarily inactive, it has much, much lower activity. T3 is very active. It's what stimulates the physiological processes of the cell. |
| This is the production part. Typically |
| Let's talk about some of the other ways that the chemistry breaks down other than just low thyroid hormone quantity. You'll see that this is a limitation with TSH. One of the things that I diagnose, TSH is just not sensitive |
| Let's look at some of the causes of over-conversion. Insulin resistance, high blood sugar, high insulin levels for a prolonged period of time and promote this over-conversion process. What ends up happening is you over-convert to T3 and the T3, when it's released into the bloodstream, the carrier proteins. (thyroid binding globulins - TBG) bind the thyroid hormone. The TBG carry the thyroid hormone through the blood , and as long as the thyroid hormone is stuck to one of these proteins it's not available for the cells of the body to use. In this pattern of over conversion of T4 to T3, the thyroid binding globulin is low. |
| What I commonly see cause this pattern of thyroid dysfunction and hypothyroid symptoms is insulin resistance and polycystic ovarian syndrome (PCOS) in women. PCOS is cysts on the ovaries, which can be promoted by insulin resistance, which by the way, will result in |
| When T3 is free for the body to use what happens is it will flood the cells. When it floods the cells, (if you're familiar with this concept of insulin resistance,) the blood sugar's high so the pancreas makes a lot of insulin, the insulin if it stays high for a prolonged period of time, the cells become less sensitized to it, so it takes more and more insulin to stimulate the cells to pull blood sugar out of the |
| This particular pattern, |
| The PCOS I said here decreases the thyroid binding globulin, the blue things. What happens is you have increased free T3, so this free T3 is all over-saturating the cell and that creates thyroid hormone resistance. That resistance I was talking about which can make make you feel hypothyroid. In order to address this pattern, you've got to address insulin resistance, you've got to address increased testosterone, and work on these mechanisms to support this process. Sometimes you have to focus on supporting the liver to clear out some excessive hormones. Let's talk about what this pattern would look like with some labs. |
| TSH, the numbers that the doctors usually check would be normal. It's not going to be affected by this because remember, the primary hormone that affects this feedback to the brain and that will suppress or change TSH is going to be T4. This is not going to substantially change TSH, typically. What you'll see here is TSH will be normal. You go to your doctor, there's problems going on, you feel bad, you know you don't feel good. They're like, okay we'll check your thyroid, they check TSH and no problem, you're normal. It's normal, it's not your thyroid and it can lead to a lot of frustration, lots of frustration because doctors don't necessarily understand this, just because they haven't been exposed to it, they haven't been taught it. There can be problems, right? You know you don't feel well and it can be frustrating for anyone. It's frustrating for me when I can't figure out what's going on with someone. I don't always figure out what's going on with people. The body's complex and I don't know everything. But I will tell you that TSH and this pattern is typically normal. |
| Total T4 is typically normal with this pattern. What you want to look at to really detect this pattern is typically you want to look at the T3 uptake which is very infrequently ordered. I see labs all the time that people have had done and very, very rarely is T3 uptake ordered. T3 uptake is the ability basically, let's just say it simply enough, that it's the ability of your body to uptake and use the thyroid hormone that's there. It actually has to do with receptors available and ... Don't worry about it. Let's just say T3 uptake just means can your body uptake and use the thyroid hormone that's in circulation. If the T3 uptake is high or near high, then that means that there's probably a lot of thyroid hormone that's saturating the cell, so you have a very high uptake. This is the key thing right here is T3 uptake being higher and in combination with free T3, I just basically, I didn't have room to write it in, so it's just the same. |
| If free T3 tends to be high or near high, it doesn't have to be lab high, it can be really close to near the high-end and we can see these types of problems patterns develop causing resistance to the T3 in circulation. The same goes for the T3 uptake. T3 uptake doesn't have to be lab high, it can be near the high end. These things can be very close to the high end and this can be the pattern that's occurring, that's actually happening. The key things here, TSH normal, T4 normal, T3 uptake is going to be high or near high, free T3 is going to be high or near high. These labs are how you're going to detect this pattern. Also, of |
| To address this, what we have to do is we have to always figure out the blood sugar component and consider what is driving the over conversion. Usually, we do that with diet, nutrition, and exercise. We have to get you moving. It doesn't mean that you have to go and do CrossFit, but it does mean that you need to be moving your body. You need to start driving the cells and the body's utilization of blood sugar for energy. We work on this nutritionally to support these patterns with nutritional compounds. We just try to see what we can do. |
| I hope this has been helpful. This is a pattern that can come up a lot with women. A lot of women have PCOS, it's very, very common and I wanted to make sure that I shared this with you guys. This is where you're going to start learning how to become your own advocate and ask intelligent questions to help you get to the root part of the problem. If you guys need anything, let us know. Please do feel free to share this information with other people because there's so many people, millions and millions of people that are struggling with thyroid dysfunction and they have no idea why. This could be a piece of the puzzle for a lot of people. Please do share this if you don't mind and let us know if you have any questions. Post your questions below and definitely continue to be your own advocate and continue to learn and I'll keep teaching. I appreciate you guys and hope you have a wonderful day. Thanks for tuning in to check this out. |
