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Autoimmune Disease: Treatments and Outcomes

Autoimmune disease is a type of health condition in which the body’s immune system attacks its own healthy cells and tissues. Despite medical advancement, treatment of autoimmune conditions can be complex, and outcomes vary greatly depending on the individual and the specific condition. Treatment options range from medications to lifestyle changes and more, as researchers continue to explore new therapies to improve outcomes for those affected by autoimmune disease.

Chronic conditions, hormonal fluctuations, brain fog, weight gain, muscle pain, and metabolic syndrome are just a few examples of clues pointing to autoimmune disease.

Why are women more affected by autoimmune disease than men?

Women are more likely to be affected by autoimmune disease than men due to a variety of factors. One of the primary reasons is that women’s immune systems are naturally more active and sensitive than those of men. This increased activity can cause the body to mistakenly target its own tissues, leading to the development of autoimmune disease. Additionally, hormones such as estrogen and progesterone can also play a role in triggering autoimmune responses in women. In some cases, these hormones can create an environment that is more conducive for the development of autoimmune conditions, such as lupus or rheumatoid arthritis. Lastly, environmental factors also appear to contribute to a greater prevalence of autoimmunity in women compared to men. Exposure to certain toxins and pollutants can increase susceptibility for developing autoimmune disease, and studies suggest that this is especially true for women due to their level of exposure from working outside or living where pollution levels are high.

Overall, it seems clear that women are disproportionally affected by autoimmune disease when compared to men, with various biological and environmental factors all playing a part.

In the vast majority of cases, it takes three underlying causes to create a full-blown autoimmune disease

Autoimmune diseases occur when the body’s immune system mistakenly attacks healthy cells. These diseases can range from mild, such as hay fever or celiac disease, to more serious conditions like lupus and rheumatoid arthritis. The underlying causes of autoimmune diseases are complex, but typically involve a combination of genetic susceptibility, environmental triggers, and an abnormal immune reaction.

Genetic Susceptibility

The functional medicine approach factors in genetic links when looking for the root cause of autoimmune disease.

Our genes play a major role in determining our risk for developing an autoimmune disorder. While it is not yet known which genes increase the risk of getting an autoimmune disorder, research indicates that some people have a higher risk due to their genetic makeup. This means that if someone has a family history of autoimmune disorders, they may be more likely to develop one themselves.

Environmental Triggers

Most autoimmune diseases can often be directly traced back to environmental factors such as toxins, molds and allergens.

Certain environmental factors may trigger an abnormal immune system response in those who are genetically predisposed to an autoimmune disorder. Examples of common triggers include stress, exposure to certain toxins or chemicals, changes in diet or lifestyle habits, infections by certain bacteria or viruses, and long-term use of certain medications.

Abnormal Immune System Response

An autoimmune patient has immune cells that can produce an autoimmune reaction if the body cannot distinguish between self and nonself. Then the body produces autoantibodies that attack normal cells by mistake.

In some cases, the immune system may respond abnormally even when no environmental triggers have been identified. This is often due to malfunctioning regulatory T-cells that are responsible for regulating the immune system’s response to foreign substances. When these cells do not function properly, the immune system may become overactive and attack healthy cells instead of attacking only foreign invaders like it should.

The combination of these three factors – genetic susceptibility, environmental triggers and abnormal immune responses – can create a perfect storm for a full-blown autoimmune disease in those who are predisposed to them. It is important for those at risk for developing an autoimmune disorder to take proactive steps to protect their health such as eating a balanced diet; exercising regularly; avoiding exposure to toxins; managing stress levels; and speaking with their doctor about treatments that may help reduce symptoms and prevent flare-ups

Conventional Treatment

Conventional treatments for autoimmune disorders typically involve the use of prescription medications. These medications are designed to reduce inflammation, suppress the immune system, and target specific antibodies or cells that are causing the autoimmune disorder. Commonly used medications include corticosteroids, immunosuppressants, biologics, and monoclonal antibodies. Corticosteroids can be taken orally or via injection to reduce inflammation and help manage symptoms. Immunosuppressants work by suppressing the activity of certain cells in the body that cause an overactive immune response. Biologics are usually injections that act on specific parts of the immune system to reduce inflammation associated with autoimmune disorders. Monoclonal antibodies, while newer on the market, can be used to target and block specific proteins in order to stop disease progression.

In addition to pharmaceuticals, lifestyle changes such as diet modification and stress management may be recommended for treating autoimmune disorders as well as reducing their symptoms. Eating a healthy diet rich in fruits, vegetables, and whole grains helps support your overall health and may help alleviate some of your symptoms. Taking steps to reduce stress levels such as deep breathing exercises or yoga can also help stimulate a calming response within your body which supports healing from within.

Modifiable Lifestyle Factors: Nutrition, Exercise, and Meditation

Living with an autoimmune disease can be a difficult and trying experience. However, through lifestyle changes and modifications, it is possible to manage the symptoms of autoimmune diseases and lead a healthier life. Modifiable lifestyle factors such as physical activity, nutrition, stress management, social support networks, and sleep hygiene are all important elements for managing autoimmune diseases. Making these changes can help one better understand the disease and make informed decisions about how to properly manage their condition.

Nutrition

If leaky gut is suspected as the root cause for chronic illness and/or autoimmune disorders dietary interventions like an anti inflammatory diet can help treat symptoms and get to the root cause and help balance gut bacteria.

Nutrition is an important modifiable lifestyle factor for managing autoimmune disease symptoms. Eating anti-inflammatory foods, such as leafy greens, legumes and fatty fish, as well as limiting processed foods can help reduce inflammation. Additionally, avoiding trigger foods and food sensitivities, such as gluten or dairy, can also help manage symptoms.

Exercise

Mild to moderate exercise is known to be good for preventing cardiovascular disease, but it's also one of the best stress management techniques to help keep cortisol (stress hormone) at a healthy level.

Exercise is another important modifiable lifestyle factor that can help manage autoimmune disease symptoms. Incorporating moderate physical activity into one’s routine can improve overall health and potentially reduce the severity of the symptoms associated with the condition. Strength training in particular has been linked to improved quality of life for those with autoimmune conditions.

Meditation

Mental health is important.  One way to regulate cortisol levels is through meditation. Regulating cortisol levels is important to immune function.

Meditation can be another beneficial modifiable lifestyle factor for managing autoimmune disease symptoms. Studies have found that mindfulness practices can reduce stress levels, which may in turn reduce flares from autoimmune conditions in some cases. Additionally, taking time to practice deep breathing exercises each day may also calm the nervous system and promote relaxation and better overall health.

Leaky Gut

Leaky gut, also known as increased intestinal permeability, is linked to the development of autoimmune diseases. Generally, the body’s immune system protects it from foreign invaders such as bacteria and viruses by creating a barrier between the inside of our bodies and the outside environment. However, when this barrier is broken down due to leaky gut, it allows these foreign invaders to enter into our bodies and trigger an immune response. This can then cause an autoimmune disease to develop. For example, if a person has leaky gut and is exposed to gluten from food products such as bread or pasta, their body may recognize these proteins as a foreign invader and mount an immune response against them. This can lead to an autoimmune disease such as celiac disease or even multiple sclerosis, which are both caused by the body attacking its own tissues due to a misidentification of self. Therefore, it is important to maintain a healthy gut so that we can prevent leaking and subsequent autoimmune diseases.

Gut Health

The root cause of many autoimmune disorders can be connected to inflammatory bowel disease or leaky gut.  An anti inflammatory diet such as autoimmune paleo diet can help balance gut bacteria.

Gut health is incredibly important when it comes to autoimmune diseases. When the gut’s microbiome (the population of bacteria, fungi and other organisms residing in the digestive tract) is out of balance, it can lead to increased inflammation throughout the body, which can make autoimmune disease worse. Moreover, an imbalance in the gut microbiota has been linked to a variety of chronic illnesses including inflammatory bowel disease and rheumatoid arthritis.

Having a healthy gut is essential for supporting your body’s natural defense system. For people with autoimmune conditions, a healthy gut means fewer flare-ups and better overall health. Eating a balanced diet rich in probiotic foods like yogurt, kefir and sauerkraut can help restore balance in the microbiome and reduce inflammation throughout the body. Consuming prebiotic foods such as bananas, onions and garlic can also promote beneficial bacteria growth in the gut that helps improve overall immunity. Supplementing with probiotics or taking an antimicrobial supplement may also be beneficial if recommended by your doctor.

In addition to nutrition, reducing stress levels and getting adequate rest can also help support a healthy gut–immune system connection. Exercise increases circulation and helps reduce inflammation, while relaxation techniques like yoga or meditation can help lower stress hormones that can cause inflammation in the body

Is autoimmune disease reversible?

Autoimmune diseases are complex and can be difficult to treat. While there is no one-size-fits-all answer, some autoimmune diseases may be reversible if treated early and properly. In general, treatments focus on reducing inflammation and preventing tissue damage, and may include lifestyle changes, dietary modifications, medications, or surgery. However, not all of these treatments are effective for every person or every autoimmune disease.

For some people with milder forms of autoimmune diseases, the symptoms may eventually improve or go away completely without treatment. In other cases, a combination of treatments may help someone manage their symptoms more effectively than any single treatment alone.

In any case, it is important to speak with a healthcare professional to determine the best treatment plan for your particular situation. It is also important to remember that even when symptoms are managed effectively, an autoimmune disease cannot always be reversed completely.

Functional Medicine Labs to Test for Autoimmunity

Functional medicine labs are becoming increasingly more popular as a way to test for autoimmunity. Functional medicine focuses on restoring balance to the body, and can help identify underlying causes of autoimmune diseases. Common functional medicine tests used to diagnose autoimmune disease include complete blood count (CBC), chemistry panel, C-reactive protein (CRP) test, and erythrocyte sedimentation rate (ESR). These tests measure inflammation in the body and can help detect antibodies or other markers related to an autoimmune disease. Other tests that may be recommended include thyroid function tests, food sensitivity testing, stool analysis, and genetic testing. All these tests help doctors narrow down possible diagnoses and create treatment plans tailored to the patient’s individual needs. It’s important for patients with suspected autoimmune disease to discuss their situation with a doctor trained in functional medicine before undergoing any testing or starting any new treatment plan.

Interested in exploring a functional medicine approach to autoimmune disease?

Exploring a functional medicine approach to autoimmune disease is an area of great interest for many individuals and medical professionals alike. Functional medicine combines traditional Western medicine with a holistic healthcare approach that focuses on restoring balance in the body through lifestyle and dietary modifications, as well as targeted supplementation when necessary. This approach recognizes that autoimmune conditions are complex and require a comprehensive, individualized strategy to address their root cause rather than simply treating symptoms.

In particular, functional medicine’s emphasis on identifying underlying imbalances can be invaluable in helping individuals suffering from autoimmune conditions to better understand what has gone wrong within their bodies and how they can make meaningful changes in order to improve their overall health and wellbeing. Additionally, this form of treatment encourages people to take ownership of their own health journey by making diet and lifestyle changes according to their specific needs. As such, this type of treatment could offer great potential for those looking for a more personalized approach to managing autoimmune disease without having to rely heavily on medication or surgery.

A few of the most common autoimmune diseases in the United States include

Autoimmune diseases are on the rise in the United States, with an estimated 24 million Americans living with one or more autoimmune conditions. Some of the most prevalent and well-known autoimmune diseases include:

1. Type 1 Diabetes – A chronic condition in which the body does not produce enough insulin to regulate blood sugar levels. Symptoms may include frequent urination, extreme thirst and fatigue.

2. Rheumatoid Arthritis – An inflammatory disease that causes joint pain and stiffness, as well as swelling and inflammation of other areas such as eyes, lungs, heart and skin.

3. Systemic Lupus Erythematosus (SLE) – Affecting almost all organ systems of the body, symptoms can range from joint pain and skin rashes to hair loss and chest pains. In severe cases, SLE can result in damage to internal organs such as kidneys or lungs.

4. Celiac Disease – A digestive disorder where people have an intolerance to gluten which can cause severe diarrhea, bloating and abdominal pain when wheat products are consumed.

5. Multiple Sclerosis (MS) – An unpredictable neurological disorder that results in vision problems, muscle weakness or spasms, difficulty coordinating movement or controlling bladder/bowel function, among other symptoms that vary from person to person depending on severity of the condition.

Medications and Biologic Drugs

There is no one-size-fits all for treating autoimmune disease.  Know the risks of any medications and make an informed decision before beginning any protocol.

Biologic drugs, also known as biologics, are a type of medication used to treat autoimmune diseases. Autoimmune diseases are those in which the body’s immune system attacks healthy cells and tissues by mistake. Biologic drugs work by targeting specific molecules that are involved in the abnormal activity of the immune system and blocking their effects. Examples of biologic drugs include adalimumab (Humira), rituximab (Rituxan), abatacept (Orencia), and infliximab (Remicade).

These medications can be administered through injections, infusions, or self-injections depending on the drug. Common side effects of biologics include injection site reactions, headache, nausea, fever, chills, rash, and upper respiratory infections. Some people may experience more serious side effects such as increased risk of infection or cancer due to suppression of the immune system while taking these medicines. It is important to discuss any potential risks with a doctor before starting a biologic drug regimen.

Biologic drugs have been shown to be effective for treating many autoimmune diseases including rheumatoid arthritis, psoriasis, Crohn’s disease, ulcerative colitis, ankylosing spondylitis and multiple sclerosis. The effectiveness varies from person to person and it is important to weigh the benefits versus risks when considering these medications. In addition to taking these medications regularly it is also important that patients follow other lifestyle modifications such as getting enough restful sleep and avoiding stress to help manage their symptoms.

Functional Medicine Treatment for Autoimmune Disease

Functional medicine is a field of medicine that takes a holistic approach to treating chronic illnesses, such as autoimmune diseases. It uses a combination of alternative and conventional treatments to address the physical, mental, and social aspects of health. The goal of functional medicine treatment for autoimmune disease is to support the body’s natural ability to heal itself by addressing the underlying causes of the condition.

The first step in functional medicine treatment for autoimmune disease is to identify any potential triggers or underlying conditions. This includes lifestyle factors such as diet, environmental toxins, stress management, sleep patterns, and exercise habits. A functional medicine practitioner will also assess any genetic predispositions or nutrient deficiencies that could be contributing to the condition. Once these factors have been identified, a customized plan can be created to address them specifically.

The second step in functional medicine treatment for autoimmune disease is to restore balance within the body through dietary changes and supplements tailored to individual needs. Examples include elimination diets that remove particular foods or food groups from the diet; nutrient-dense diets; and supplementation with vitamins, minerals and herbs to support overall health and reduce inflammation. Additionally, practitioners may recommend other therapies such as yoga, acupuncture and mind-body techniques like meditation or relaxation exercises.

Ultimately, the goal of functional medicine treatment for autoimmune diseases is not just symptom relief but also long-term remission through correcting imbalances within the body’s systems. By treating all aspects of health holistically with an individualized approach tailored to each patient’s needs, individuals can experience better outcomes with fewer side effects than traditional treatments alone.

It’s time to finally Get to the Root of your health concerns

In order to get to the root cause of health concerns, it is important to look beyond the surface level symptoms and delve deeper into the underlying causes. This can be done through a thorough examination of medical history and lifestyle habits, such as diet and exercise. Additionally, psychological factors and environmental triggers should also be considered when looking for the source of an illness or health issue. A doctor or specialist may be able to provide insight into potential causes by conducting tests or ordering additional tests if necessary.

The goal is to uncover any underlying conditions that may have contributed to the current condition so that they can be addressed and treated appropriately. Treatment plans must take into account not only the physical symptoms but also any mental or emotional aspects that could have caused or contributed to the patient’s symptoms.

Ultimately, getting to the root cause of a health concern requires patience and determination in order to discover what is causing it in the first place. By working with a healthcare provider who is willing to thoroughly evaluate all avenues, it will be possible to find solutions that address both short-term relief of symptoms as well as long-term healing from the roots of an illness or health concern.

Comprehensive Thyroid Panel

A functional medicine doctor will likely order advanced lab tests to look for autoimmune markers that traditional doctors are sometimes hesitant to order due to insurance mandates.

A comprehensive thyroid panel is a set of tests used to screen for and diagnose thyroid-related disorders. It typically includes measurements for the hormones thyroxine (T4), triiodothyronine (T3), and thyroid stimulating hormone (TSH). It may also include other metabolites such as reverse T3 or TSH receptor antibodies. The thyroid panel can be used to measure levels of these hormones in order to diagnose hypothyroidism, hyperthyroidism, or Graves’ disease.

In addition to measuring thyroid hormone levels, a comprehensive thyroid panel can also help detect autoimmunity-related disorders such as Hashimoto’s disease. This type of autoimmune disorder typically presents with high levels of TSH receptor antibodies that are not present in healthy individuals. By detecting such antibodies, the comprehensive thyroid panel can help to confirm the presence of an autoimmune disorder and provide guidance on appropriate treatment.

Furthermore, a comprehensive thyroid panel may also include tests for free thyroxine index, total T4, free T3 and Total T3 which can further help determine the underlying cause of any abnormal findings from the initial hormone assessments. Ultimately, this helps provide physicians with additional information about patients’ specific conditions in order to optimize their treatment plans.

Comprehensive Stool Test for Gut Health

A comprehensive stool test is an important diagnostic tool for identifying problems in the digestive tract. It involves collecting and analyzing a sample of fecal matter, which can reveal a wide range of potential issues. The test can be used to help diagnose conditions such as intestinal permeability, irritable bowel syndrome (IBS), celiac disease, Crohn’s disease, parasitic infections, and colorectal cancer. Depending on what information the doctor is seeking, components of this test may include a physical examination of the stool sample under a microscope, looking for clues to gut health such as bacteria or parasites; testing for blood in the stool; measuring levels of fats and carbohydrates; examining the sample for evidence of inflammation or infection; and conducting genetic tests to detect specific diseases. The results of these tests are generally available within two to three days after they are performed, allowing doctors to make quick treatment decisions if necessary.

Autoimmune Protocol (AIP)

The Autoimmune Protocol (AIP) is an elimination diet intended to reduce inflammation, calm autoimmune reactions, and support the body in healing itself. The diet removes foods that are known to cause inflammation and can trigger immune responses. It includes nutrient-dense whole foods such as grass-fed meats, wild-caught fish, organic vegetables and certain natural fats. AIP eliminates grains, legumes, dairy and eggs, as well as processed foods and vegetable oils. The goal of the protocol is to restore balance in the gut microbiome by removing inflammatory triggers from the diet while replenishing beneficial bacteria with fermented foods. This helps to reduce systemic inflammation, improve digestion, boost energy levels and stabilize moods. People following the AIP diet often report improved symptom control for conditions like lupus and rheumatoid arthritis. The AIP protocol is a great way to achieve better health and wellbeing without turning to medication or drastic lifestyle changes. Taking time to focus on healing your body through nutrition can bring about long-term relief from chronic pain and illness.

Dr. Shook has psoriasis and Hashimoto's disease and has trained extensively in functional medicine, epigenetics, and human performance optimization. DrBradShook.com is a resource to help people with Hashimoto's disease, thyroid dysfunction, and other autoimmune conditions learn more about how they can complement their current medical care and support their thyroid and autoimmunity naturally.